Sex-Biased Gene Expression
David C. Page lab (Whitehead Institute/MIT Biology) has conducted comprehensive studies identifying hundreds of genes expressed differently in males and females across numerous tissues and species, providing a foundational understanding of sex-based biological distinctions.
MORE
Engineering Sex-Specific Research Models (NAMs)
Professor Linda Griffith and her collaborators are pioneering Novel Alternative Methods (NAMs), including “living patient avatars” and “organs-on-chips,” to create research models that accurately reflect female physiology, particularly by controlling steroid hormone environments. Key collaborators include Doug Lauffenburger and David Trumper.
SeXX + Immunity Initiative
Co-led by The Tal Research Group and Professor Linda Griffith, this initiative explores how biological sex and sex hormones influence immune responses and chronic illness, aiming to build better patient avatars for studying these differences.
MORE